Highly Stable Indomethacin Glasses Resist Uptake of Water Vapor

TitleHighly Stable Indomethacin Glasses Resist Uptake of Water Vapor
Publication TypeJournal Article
Year of Publication2009
AuthorsDawson, K. J., K. L. Kearns, M. D. Ediger, M. J. Sacchetti, and G. D. Zografi
JournalJournal of Physical Chemistry B
Volume113
Pagination2422-2427
ISBN Number1520-6106
Accession NumberWOS:000263529500027
KeywordsAMORPHOUS STATE, DIFFUSION, PART I, PARTIAL MOLAR VOLUME, PHYSICAL-PROPERTIES, POLYMER GLASSES, SMALL MOLECULES, SORBED, T-G, TRANSPORT-PROPERTIES, WATER
Abstract

Mass uptake of water vapor was measured as a function of relative humidity for indomethacin glasses prepared using physical vapor deposition at different substrate temperatures. Highly stable glasses were produced on substrates at 265 K (0.84T(g)) by depositing at 0.2 nm/s while samples similar to melt-cooled glasses were produced at 315 K and 5 nm/s. Samples deposited at 315 K absorb approximately the same amount of water as glasses prepared by supercooling the melt while stable glasses absorb a factor of 5 less water. Unexpectedly, the diffusion of water in the stable glass samples is 5-10 times faster than in the glass prepared by cooling the liquid.

DOI10.1021/jp808838t
Alternate JournalJ. Phys. Chem. B