Title | Highly Stable Indomethacin Glasses Resist Uptake of Water Vapor |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Dawson, K. J., K. L. Kearns, M. D. Ediger, M. J. Sacchetti, and G. D. Zografi |
Journal | Journal of Physical Chemistry B |
Volume | 113 |
Pagination | 2422-2427 |
ISBN Number | 1520-6106 |
Accession Number | WOS:000263529500027 |
Keywords | AMORPHOUS STATE, DIFFUSION, PART I, PARTIAL MOLAR VOLUME, PHYSICAL-PROPERTIES, POLYMER GLASSES, SMALL MOLECULES, SORBED, T-G, TRANSPORT-PROPERTIES, WATER |
Abstract | Mass uptake of water vapor was measured as a function of relative humidity for indomethacin glasses prepared using physical vapor deposition at different substrate temperatures. Highly stable glasses were produced on substrates at 265 K (0.84T(g)) by depositing at 0.2 nm/s while samples similar to melt-cooled glasses were produced at 315 K and 5 nm/s. Samples deposited at 315 K absorb approximately the same amount of water as glasses prepared by supercooling the melt while stable glasses absorb a factor of 5 less water. Unexpectedly, the diffusion of water in the stable glass samples is 5-10 times faster than in the glass prepared by cooling the liquid. |
DOI | 10.1021/jp808838t |
Alternate Journal | J. Phys. Chem. B |